Modulation of endothelial cell function by normal polyspecific human intravenous immunoglobulins: a possible mechanism of action in vascular diseases.

Clinical Application and Functional Mechanisms of Intravenous Immunoglobulin: an Overview

Previous, Intravenous Immunoglobulin (IVIG) has been used for treatment of patients with immunodeficiency. However, recent studies have shown that IVIG is a suitable approach for treatment of inflammatory and autoimmune diseases. Although the exact mechanism of IVIG action is not well known, recent findings have demonstrated that IVIG impacts on expression and function of FC receptors of immuno...

Patterns of Vascular Endothelial Growth Factor Expression in Hematopoietic Malignant Cells

Background and Objective: Vascular endothelial growth factor (VEGF) is a cytokine which is overexpressed in many malignant cancers including leukemia. VEGF plays an important role in tumor invasion and metastasis. Determination of the pattern of VEGF expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...

Novel Mechanism of Action of IVIg Involving Human Lymphocytes and Monocytes: A Polyspecific IgG (IVIg) Induce Apoptosis in Therapeutic Preparations of Normal

Design of a humanized anti vascular endothelial growth factor nanobody and evaluation of its in vitro function

Objective(s): Nanobodies, the single domain antigen binding fragments of heavy chain-only antibodies occurring naturally in camelid sera, are the smallest intact antigen binding entities. Their minimal size assists in reaching otherwise largely inaccessible regions of antigens. However, their camelid origin raises a possible concern of immunogenicity when used for human therapy. Humanization is...

Immunomodulating effects of intravenous immunoglobulin in autoimmune and inflammatory diseases.

Intravenous immunoglobulin (IVIg) therapy is increasingly used for its immunomodulating properties in a wide range of pathological conditions including autoimmune diseases, systemic inflammatory diseases and allotransplantation. Intravenous immunoglobulins are obtained from a pool of several thousand healthy blood donors. They are composed of intact IgG with a distribution of subclasses corresp...